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A pan-cancer-bioinformatic-based literature review of TRPM7 in cancers
Hengrui Liu1, James P Dilger1, Jun Lin1
1Department of Anesthesiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
Abstract:
TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses based on open databases and reviewed articles that provided evidence for the effects of TRPM7 on cancers. The purposes of this paper are 1) to provide a pan-cancer overview of TRPM7 in cancers; 2) to summarize evidence of TRPM7 effects on cancers; 3) to identify potential future studies of TRPM7 in cancer. Bioinformatics analysis revealed that no cancer-related TRPM7 mutation was found. TRPM7 is aberrantly expressed in most cancer types but the cancer-noncancer expression pattern varies across cancer types. TRPM7 was not associated with survival, TMB, or cancer stemness in most cancer types. TRPM7 affected drug sensitivity and tumor immunity in some cancer types. The in vitro evidence, preclinical in vivo evidence, and clinical evidence for TRPM7 effects on cancers as well as TRPM7 kinase substrate and TRPM7-targeting drugs associated with cancers were summarized to facilitate comparison. We matched the bioinformatics evidence to literature evidence, thereby unveiling potential avenues for future investigation of TRPM7 in cancers. We believe that this paper will help orient research toward important and relevant aspects of the role of TRPM7 in cancers.
Insights
Transient Receptor Potential Melastatin 7 (TRPM7) shows aberrant expression in most cancers, impacting drug sensitivity and tumor immunity, though not linked to mutations or survival. Further research into TRPM7
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- Transient Receptor Potential Melastatin 7 (TRPM7) is a channel protein with kinase activity implicated in various cellular processes.
- Previous studies suggest a potential role for TRPM7 in cancer development and progression.
- A comprehensive understanding of TRPM7's multifaceted roles in diverse cancer types is lacking.
Purpose of the Study:
- To conduct a pan-cancer analysis of TRPM7 expression, mutations, and clinical correlations.
- To consolidate existing evidence on TRPM7's impact on cancer, including in vitro, preclinical, and clinical data.
- To identify future research directions for TRPM7 in oncology.
Main Methods:
- Utilized bioinformatics analyses on open cancer databases (e.g., TCGA).
- Performed literature reviews to gather evidence on TRPM7's functional roles in cancer.
- Integrated bioinformatics findings with existing literature data.
Main Results:
- No cancer-associated TRPM7 mutations were identified.
- TRPM7 exhibits aberrant expression across most cancer types, with variable patterns.
- TRPM7 influences drug sensitivity and tumor immunity in specific cancers, but generally lacks association with survival, TMB, or stemness.
Conclusions:
- TRPM7's role in cancer is complex, primarily involving altered expression rather than mutation.
- TRPM7 impacts specific cancer hallmarks like drug response and immune infiltration.
- This study provides a foundation for targeted future research on TRPM7 in cancer therapy.
