Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Toxins01:36

Types of Toxins

1.9K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.9K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

31
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
31
Autoimmune Disorders01:29

Autoimmune Disorders

618
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
618
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.8K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.0K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

46
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
46

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiology, antimicrobial resistance, and mortality of bloodstream infections in hemodialysis patients: an 11-year retrospective cohort study from southern Saudi Arabia.

BMC nephrology·2026
Same author

Psychometric evaluation and discriminative validity of the Short-Form Brief Pain Inventory across nociceptive, neuropathic, and nociplastic pain mechanisms.

The journal of pain·2026
Same author

The American College of Rheumatology Updated Recommended Methods for Development of Disease Classification and Response Criteria.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Complexity to clarity: Advancing the science and care of systemic sclerosis.

Best practice & research. Clinical rheumatology·2026
Same author

Physical rehabilitation interventions for hand function in people with systemic sclerosis.

Best practice & research. Clinical rheumatology·2026
Same author

Screening, monitoring and treatment of interstitial lung disease in systemic sclerosis.

Best practice & research. Clinical rheumatology·2026

Related Experiment Video

Updated: Aug 23, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.1K

Environmental Risks for Systemic Sclerosis.

Hana Alahmari1, Zareen Ahmad1, Sindhu R Johnson2

  • 1Toronto Scleroderma Program, Mount Sinai Hospital, 2nd Floor, Box 9, 60 Murray Street, Toronto, Ontario M5T 3L9, Canada.

Rheumatic Diseases Clinics of North America
|November 4, 2022
PubMed
Summary

Environmental factors like occupational exposures and microbiome changes are increasingly linked to systemic sclerosis (SSc). Understanding these triggers is crucial for developing protective measures and understanding SSc pathogenesis.

Keywords:
Environmental risk factorsOccupational risk factorsSclerodermaSystemic sclerosis

More Related Videos

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.2K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

526

Related Experiment Videos

Last Updated: Aug 23, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.1K
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.2K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

526

Area of Science:

  • Environmental Medicine
  • Immunology
  • Genetics

Background:

  • Growing evidence suggests environmental factors contribute to systemic sclerosis (SSc) development.
  • Identified factors include occupational exposures, chemicals, medications, and microbiome alterations (dysbiosis).
  • These exposures may trigger aberrant immune responses via epigenetic modifications.

Purpose of the Study:

  • To explore the link between environmental factors and systemic sclerosis (SSc).
  • To identify potential triggers that initiate the disease process.
  • To inform the development of protective measures against SSc.

Main Methods:

  • Literature review of studies investigating environmental exposures and SSc.
  • Analysis of proposed mechanisms, including epigenetic regulation and immune response.
  • Identification of key environmental factors implicated in SSc pathogenesis.

Main Results:

  • Environmental factors are strongly associated with the development of SSc.
  • Epigenetic dysregulation is a potential mechanism linking environmental exposures to SSc.
  • Occupational exposures, chemical materials, medications, and microbiome dysbiosis are key areas of investigation.

Conclusions:

  • Environmental factors play a significant role in the pathogenesis of systemic sclerosis (SSc).
  • Further research into specific triggers can enhance our understanding of SSc.
  • Identifying and mitigating environmental exposures may lead to effective protective strategies for SSc.