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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Identification of Novel Risk Loci for Common B-Cell Lymphoma Subtypes Through Cross-Trait Analysis with Idiopathic Inflammatory Myopathies.

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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Environmental Risks for Inflammatory Myopathies.

Weng Ian Che1, Ingrid E Lundberg2, Marie Holmqvist3

  • 1Department of Medicine, Solna, Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna, Stockholm 171 76, Sweden; Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

Rheumatic Diseases Clinics of North America
|November 4, 2022
PubMed
Summary
This summary is machine-generated.

Environmental factors like UV radiation, smoking, viruses, and pollutants may contribute to adult-onset idiopathic inflammatory myopathies (IIMs). Further research is needed to clarify these links and challenges in IIM development.

Keywords:
Antisynthetase syndromeEnvironmental factorsIdiopathic inflammatory myopathiesInfectious agentsMyositisPollutantsSmokingUltraviolet radiation

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Area of Science:

  • Rheumatology and Environmental Medicine

Background:

  • Adult-onset idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune diseases.
  • The etiology of IIMs is complex, involving genetic predisposition and environmental triggers.

Purpose of the Study:

  • To review current evidence on external environmental factors implicated in the development of adult-onset IIMs.
  • To discuss the potential role of these factors and identify future research directions.

Main Methods:

  • Comprehensive literature review of studies investigating environmental exposures and IIMs.
  • Analysis of evidence for factors including ultraviolet radiation, infections, pollutants, medications, and vitamin D.

Main Results:

  • Suggestive evidence links ultraviolet radiation, smoking, viral infections, air pollutants, statin medications, and vitamin D deficiency to IIMs.
  • These factors may play a role in the pathogenesis of IIMs.

Conclusions:

  • Environmental factors are increasingly recognized as potential contributors to adult-onset IIMs.
  • Further investigation is crucial to elucidate causal relationships and address current research challenges.