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Updated: Aug 23, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Postoperative opioid administration and post-traumatic stress symptoms in preschool children after cardiac surgery
Kelly A Davis1, Mary S Dietrich2, Mary Jo Gilmer3
1Vanderbilt University School of Nursing, Vanderbilt University, 461 21st Avenue South, Nashville, TN 37240, USA; Division of Pediatric Critical Care, Vanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232, USA.
Insights
Total postoperative opioid use did not correlate with posttraumatic stress symptoms (PTSS) in young children after heart surgery. However, morphine showed a favorable association with PTSS in children with single-ventricle physiology.
Area of Science:
- Pediatric Cardiac Surgery
- Pain Management
- Psychological Outcomes
Background:
- Posttraumatic stress symptoms (PTSS) can affect children after surgery.
- Understanding the impact of postoperative pain management on PTSS is crucial for pediatric cardiac patients.
Purpose of the Study:
- To investigate the relationship between postoperative opioid administration and PTSS in preschool-aged children following cardiac surgery.
Main Methods:
- A cross-sectional study involving 3-6 year olds who underwent cardiac surgery.
- Survey administration and medical chart review were used.
- Opioid administration was quantified using morphine milligram equivalents, indexed to body weight.
Main Results:
- No significant relationship was found between total postoperative opioid administration and child PTSS.
- Morphine demonstrated a significant inverse relationship with PTSS scores in children with single-ventricle physiology (rs = -.57, p = .017).
Conclusions:
- Overall postoperative opioid administration did not correlate with PTSS in this cohort.
- Morphine administration was favorably associated with lower PTSS in preschoolers with single-ventricle physiology.
- Further longitudinal studies with larger sample sizes are recommended.
Purpose:
The purpose of this study was to explore relationships between postoperative opioid administration and posttraumatic stress symptoms (PTSS) in preschool-aged children surviving cardiac surgery.
Design And Methods:
This was a cross-sectional, descriptive study using survey administration and medical chart review. Primary caregivers of children aged three to six years who underwent cardiac surgery at our institution between 2018 and 2020 were invited to participate. Opioid administration was calculated according to morphine milligram equivalents and indexed to the child's body weight. Caregivers completed the Young Child Posttraumatic Stress Disorder Checklist to explore child PTSS. We used correlational methods to assess the strength and direction of relationships between postoperative opioid administration and child PTSS.
Results:
We did not find a statistically significant relationship between total postoperative opioid administration and child PTSS. When analyzing individual opioid agents, morphine did show a significant inverse relationship to YCPC scores (rs = -.57, p = .017) in children with single ventricle physiology.
Conclusions:
Total postoperative opioid administration was not statistically significantly related to child PTSS in our sample. Differing patterns of association were noted among children with single- versus bi-ventricular physiology. Postoperative morphine administration was favorably associated with PTSS in children with single-ventricle physiology.
Practice Implications:
Nurses caring for preschool children who undergo cardiac surgery should anticipate the potential development of PTSS in their patients. Studies using larger sample sizes and longitudinal design are needed to replicate the significant relationship between morphine administration and PTSS in preschoolers with single-ventricle physiology.
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