Related Experiment Video
Updated: Aug 23, 2025
Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
Published on: April 11, 2025
Whether surgical resection or biopsy makes difference in single lesion primary central nervous system lymphoma: a
Xin Cheng1,2,3, Haoran Chen1,4, Chongran Sun1,2
1Department of Neurosurgery, School of Medicine, 2nd Affiliated Hospital, Zhejiang University, 88# Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Background:
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive disease. The role of surgical resection in PCNSL has always been the center of debate. Here we investigated the clinical and follow-up data of single lesion PCNSL operated in our center, focusing on the comparison between surgical resection and biopsy.
Methods:
All consecutive cases of single lesion PCNSL between October 2004 and December 2019 were retrospectively collected from the database of the Second Affiliated Hospital of Zhejiang University, School of Medicine. Patients were divided into resection group and biopsy group. Clinical information including age, gender, Karnofsky performance status, imaging features and postoperative treatment was collected from the medical records. All the patients were followed for survival analysis.
Results:
A total of 105 patients with PCNSL were finally involved in our analysis. Neither PFS nor OS were significantly different between the resection group and biopsy group. The univariate analysis revealed that age < 60 and therapeutic treatment were significant predictors of longer PFS and OS. In the multivariate analysis, age (HR = 3.09, 95% CI 1.31-7.28, p = 0.01) and therapeutic treatment (HR = 0.25, 95% CI 0.07- 0.83, p = 0.02) were independent prognostic markers with OS. Multivariable Cox regression analyses also revealed that only age (HR = 2.29 (95% CI, 1.11-4.71, p = 0.03) was independent prognostic marker for PFS.
Conclusions:
In single lesion PCNSL, there was no significant difference between the resection group and biopsy group for both PFS and OS. Younger age and postoperative treatment have been proved to be indicators of better prognosis.
