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Neurodevelopment in school-aged children after intrauterine exposure to antipsychotics

Lisanne Schrijver1,2, Thalia K Robakis3, Astrid M Kamperman1

  • 1Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.

Acta Psychiatrica Scandinavica
|November 5, 2022
PubMed

Insights

Prenatal exposure to antipsychotics did not show adverse effects on neurodevelopmental functioning in school-aged children. This study investigated IQ, psychiatric diagnoses, and learning problems in children exposed in utero.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • Antipsychotic use during pregnancy is rising.
  • Long-term developmental impacts on children are not well understood.

Purpose of the Study:

  • To examine the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school-aged children.
  • Investigate associations with IQ, psychiatric disorders, and learning problems.

Main Methods:

  • Cross-sectional study of 91 children (6-14 years).
  • Compared children exposed and unexposed to antipsychotics in utero.
  • Assessed neurodevelopmental outcomes using validated instruments and parental reports.

Main Results:

  • No significant associations found between prenatal antipsychotic exposure and adverse neurodevelopmental outcomes.
  • No increased likelihood of psychiatric diagnosis or learning problems reported.

Conclusions:

  • Intrauterine exposure to antipsychotics was not linked to adverse effects on IQ or neurodevelopment in school-aged children.
  • Study limitations include small sample size and sample heterogeneity, potentially limiting power to detect subtle differences.
Abstract

Keywords:
IQantipsychoticsneurodevelopmentoffspringpregnancy

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