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Swiss Evaluation Registry for Pediatric Infective Endocarditis (SERPIE) - Risk factors for complications in children

Stefanie Katharina Schuler1, Pierre Alex Crisinel2, Raphael Joye3

  • 1Pediatric Cardiology, Pediatric Heart Center, University Children's Hospital Zurich, University of Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

International Journal of Cardiology
|November 5, 2022
PubMed

Insights

Pediatric infective endocarditis (IE) is a serious heart condition in children. Staphylococcus aureus infections increase complications and mortality, highlighting the need for better prevention and treatment strategies.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Cardiac Surgery

Background:

  • Infective endocarditis (IE) in pediatric patients is a severe cardiac condition.
  • Epidemiology and clinical outcomes of pediatric IE in Switzerland are not well-documented.

Purpose of the Study:

  • To analyze the epidemiology and clinical outcomes of pediatric infective endocarditis in Switzerland.
  • To identify risk factors and complications associated with pediatric IE.

Main Methods:

  • Retrospective nationwide multicenter data analysis.
  • Inclusion of pediatric patients (<18 years) diagnosed with IE between 2011 and 2020.

Main Results:

  • 69 pediatric patients were treated for IE, with a median age of 6.4 years.
  • Congenital heart defects were present in 84% of cases, and 70% had postoperative IE.
  • Staphylococcus aureus was a predictor of severe complications (51%), including heart failure, sepsis, and embolism. Mortality was 7%.

Conclusions:

  • Pediatric IE is a severe disease with significant mortality and morbidity.
  • Staphylococcus aureus infections are linked to higher complication rates.
  • Congenital heart defects are a risk factor; prosthetic pulmonary valve involvement requires further investigation.
Abstract

Keywords:
ChildComplicationCongenital heart diseaseInfective endocarditisStaphylococcus aureus

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