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Xiaojie Wang¹, Tingting Wang², Junjie Hua¹

¹Department of Epidemiology, School of Public Health, Sun Yat-sen University, China.

The Science of the Total Environment

|November 5, 2022

Abstract

Background:

Fine particulate matter (PM_2.5), smoking, and genetic factors are associated with lung cancer. However, the relationship between PM_2.5, smoking and subtypes of lung cancer remains unclear. Moreover, it is unclear whether genetic risk modifies the impact of PM_2.5 and smoking on incident lung cancer.

Methods:

A total of 298,069 participants from the UK Biobank study without lung cancer at baseline were included in this study. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were estimated using multivariable Cox proportional models for the association of lung cancer and its subtypes with PM_2.5, smoking, and genetic risk. Potential gene-smoking or gene-PM_2.5 interactions were also estimated. We further estimated population attributable fractions for incident lung cancer.

Results:

During 10.4 years of follow-up, 1683 incident lung cancer cases were identified. Our analysis found that genetic variants, smoking, and PM_2.5 were significantly associated with incident lung cancer. For different histological types of lung cancer, the HRs for squamous cell lung carcinoma associated with PM_2.5 (per 5 microg/m³ increment) and current smoking were 2.76 (95 % CI: 1.72, 4.42, p < 0.001) and 48.64 (95 % CI: 27.96, 84.61, p < 0.001), while the HRs for lung adenocarcinoma were 1.59 (95 % CI: 1.13, 2.23, p < 0.001) and 9.89 (95 % CI: 7.91, 12.36, p < 0.001), respectively. We further found that participants with high levels of PM_2.5 pollution and high genetic risk had the highest risk of incident lung cancer (HR = 1.81, 95 % CI: 1.39, 2.35, p < 0.001), while the interaction between PM_2.5 and genetic risk was not statistically significant. We observed that the population attributable fractions of lung cancer attributable to current smoking and high PM_2.5 exposure were estimated to be 67.45 % and 17.59 %.

Conclusion:

Genetic susceptibility, smoking, and PM_2.5 are important risk factors for lung cancer. Both smoking and PM_2.5 are more closely associated with an elevated risk of squamous cell lung cancer.

Keywords:

Cohort study Histological types of lung cancer PM(2.5)UK Biobank

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