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Updated: Aug 23, 2025
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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
Published on: February 14, 2022
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Lung transplantation for lymphangioleiomyomatosis
Krishnan Warrior1, Daniel F Dilling1
1Division of Pulmonary and Critical Care, Loyola University Chicago, Stritch School of Medicine, Maywood, IL.
Summary
Lymphangioleiomyomatosis (LAM) is a rare lung disease. Lung transplantation (LTX) can improve quality of life for advanced LAM patients, with unique pre- and post-transplant considerations.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Rare Diseases
Background:
- Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease.
- LAM causes respiratory symptoms like dyspnea and pneumothorax, and extra-thoracic manifestations.
- End-stage LAM often necessitates respiratory support, including supplemental oxygen.
Purpose of the Study:
- To review the evaluation and management of lung transplantation (LTX) in patients with Lymphangioleiomyomatosis (LAM).
- To discuss disease-specific complications of LAM before and after LTX.
- To examine outcomes for LAM patients undergoing LTX.
Main Methods:
- Literature review of studies on lung transplantation for LAM.
- Analysis of pre-transplant considerations and management strategies.
- Examination of post-transplant complications and patient outcomes.
Main Results:
- LTX can enhance survival and quality of life for LAM patients with end-stage lung disease.
- Unique pre-transplant LAM complications influence management decisions.
- Specific post-transplant issues in LAM patients require careful monitoring.
Conclusions:
- Lung transplantation is a viable option for select LAM patients.
- Comprehensive management addressing LAM-specific issues is crucial for successful LTX outcomes.
- Further research into optimizing LTX for LAM is warranted.
