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Association between metabolic syndrome and mortality in patients with COVID-19: A nationwide cohort study

Hyo Jin Park1, Jin-Hyung Jung2, Kyungdo Han3

  • 1Department of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Obesity Research & Clinical Practice
|November 5, 2022
PubMed

Insights

Metabolic syndrome (MetS) significantly increases mortality risk in COVID-19 patients, especially women. Managing MetS may improve outcomes for coronavirus disease 2019 patients.

Area of Science:

  • Epidemiology
  • Public Health
  • Internal Medicine

Background:

  • Metabolic syndrome (MetS) is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
  • The impact of MetS on COVID-19 outcomes is an area of ongoing research.

Purpose of the Study:

  • To investigate the association between metabolic syndrome (MetS) and mortality in Korean patients diagnosed with coronavirus disease 2019 (COVID-19).

Main Methods:

  • Analysis of 3876 COVID-19 patients from the Korea National Health Insurance Service (NHIS)-COVID-19 database.
  • Utilized health examination data from 2015-2017 for MetS assessment.
  • Employed multivariable Cox proportional hazard regression analyses to determine mortality risk.

Main Results:

  • The prevalence of MetS was 21.0% among the study participants.
  • COVID-19 patients with MetS exhibited a significantly increased mortality risk (HR: 1.68).
  • Increased mortality risk was observed with a higher number of MetS components, particularly in women and individuals aged ≥60 years.

Conclusions:

  • The presence and severity of MetS are associated with elevated mortality risks in COVID-19 patients, notably in females.
  • Effective management of MetS may be crucial for improving clinical outcomes in coronavirus disease 2019.
Abstract

Keywords:
COVID-19Metabolic syndromeMortalitySARS-CoV-2Women

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