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Updated: Aug 2, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
Published on: April 29, 2011
Optimal flow pattern for mechanical ventilation of the lungs. 2. The effect of a sine versus square wave flow pattern
Abstract:
In four series of patients, the efficiency of ventilation of a sine wave without an end-inspiratory pause was compared to a square wave without a pause, a sine wave with a pause to a square wave with a pause, a sine wave to a sine wave with a pause, and a sine wave with a long pause to one with a short pause. The primary mode of evaluation was through simultaneous airway and arterial argon washout curves. Additional cardiopulmonary measurements were made. Results indicate: (1) a statistically significant improvement in ventilation with a sine wave with a pause; (2) a statistically significant improvement with the longer pause as compared to the short pause.
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