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The Mammary Glands01:12

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The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
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Related Experiment Video

Updated: Aug 23, 2025

Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Lobular Neoplasia.

Lilia Lunt1, Alison Coogan1, Claudia B Perez2

  • 1Department of Surgery, Rush University Medical Center, Rush University, 600 South Paulina Street, Chicago, IL 60612, USA.

The Surgical Clinics of North America
|November 6, 2022
PubMed
Summary
This summary is machine-generated.

Lobular neoplasia (LN), including atypical lobular hyperplasia and lobular carcinoma in situ, increases breast cancer risk. Early detection and counseling on screening and chemoprevention are crucial for managing this condition.

Keywords:
ALHAtypical lobular hyperplasiaBreast cancer riskCore needle biopsyHigh-risk lesionLCISLobular carcinoma in situPleomorphic lobular carcinoma in situ

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Area of Science:

  • Breast pathology
  • Oncology
  • Radiology

Background:

  • Lobular neoplasia (LN) encompasses atypical epithelial lesions like atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS).
  • LN is recognized as a significant risk factor and precursor to invasive breast cancer.
  • LCIS diagnosis elevates breast cancer risk by 7- to 10-fold compared to the general population.

Purpose of the Study:

  • To define lobular neoplasia (LN) and its clinical implications.
  • To highlight the association between LN and increased breast cancer risk.
  • To outline management strategies for patients diagnosed with LN.

Main Methods:

  • Review of pathological definitions of lobular neoplasia (LN).
  • Analysis of risk factors associated with lobular carcinoma in situ (LCIS).
  • Discussion of diagnostic procedures, including core needle biopsy (CNB).

Main Results:

  • Lobular neoplasia (LN) includes ALH and LCIS, originating in the breast's terminal duct-lobular unit (TDLU).
  • LCIS diagnosis is linked to a substantial increase in breast cancer risk.
  • Core needle biopsy (CNB) is a key diagnostic tool for LN.

Conclusions:

  • Patients with LN require counseling regarding their elevated breast cancer risk.
  • Management options for LN include enhanced screening or surgical excision.
  • Informing patients about screening and chemoprevention is essential for risk reduction.