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Comorbidity defines asthmatic patients' risk of COVID-19 hospitalization: A global perspective

Chrysanthi Skevaki1, R Sharon Chinthrajah2, Daria Fomina3

  • 1Institute of Laboratory Medicine and Pathobiochemistry, Philipps University Marburg, Marburg, Germany; Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, Marburg, Germany.

The Journal of Allergy and Clinical Immunology
|November 6, 2022
PubMed

Insights

Asthma prevalence varied significantly in hospitalized coronavirus disease 2019 (COVID-19) patients globally. Geographic differences in asthma and COVID-19 co-occurrence are linked to varying comorbidity prevalence, especially chronic obstructive pulmonary disease.

Area of Science:

  • Epidemiology
  • Pulmonology
  • Infectious Diseases

Background:

  • Global epidemiology of asthma in COVID-19 patients shows significant geographic variations.
  • Prevalence zones of high and low co-occurrence of asthma and COVID-19 are defined.

Purpose of the Study:

  • To compare asthma prevalence in hospitalized COVID-19 patients across major global hubs.
  • To apply common inclusion criteria and definitions for accurate comparison.

Main Methods:

  • A network of 6 academic hospitals was established in the United States, Germany, and Russia.
  • Clinical and laboratory data were collected for patients hospitalized with COVID-19.

Main Results:

  • Asthmatic patients were overrepresented in the US (Stanford) and underrepresented in Russia (Moscow) and Germany compared to local community prevalence.
  • Asthma prevalence did not differ between intensive care unit and non-intensive care unit patients, suggesting no increased risk for severe COVID-19.
  • Comorbidities, particularly chronic obstructive pulmonary disease, were more frequent in asthmatic COVID-19 patients in the US cohort.

Conclusions:

  • Disparities in COVID-19-associated risk among asthmatic patients are linked to geographic variations in underlying comorbidities.
  • Chronic obstructive pulmonary disease prevalence significantly influences the observed differences in asthma and COVID-19 co-occurrence globally.
Abstract

Keywords:
COPDChronic airway in inflammation prevalenceSARS-CoV-2chronic obstructive pulmonary diseasepublic health

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