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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Four new sesquiterpenes from Curcuma wenyujin
Lijia Chen1, Jingwen Liu1, Hong Wang1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Abstract:
Four new sesquiterpenes including two guaianes (1 and 2), one germacrene (3), and one nor-sesquiterpene (4), which were named as wenyujinols M-P, along with nine known sesquiterpenes (5-13) and three monoterpenes (14-16), were isolated from the rhizomes of Curcuma wenyujin. The chemical structures of 1-4 were elucidated by NMR spectroscopic, mass spectrometric data, and electronic circular dichroism (ECD) spectra analysis. The isolated compounds were evaluated for antioxidant activity via activating the transcription of Nrf2 in 293 T cells. As a result, compounds 6, 13 and 14 exhibited the Nrf2 agonist activity dose-dependently.
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