[Becoming requesting couples after their registration in oocyte donation]

Area of Science:

• Reproductive Medicine
• Infertility Treatment
• Oocyte Donation Programs

Background:

• Limited data exists on discontinuation causes in oocyte donation programs.
• Medically assisted procreation discontinuation is well-studied, but oocyte donation is not.
• This study addresses the gap in understanding oocyte donation program cessation.

Purpose of the Study:

• To determine the primary causes of discontinuation in oocyte donation programs.
• To analyze the frequency of each discontinuation reason.
• To exclude live births as a reason for discontinuation.

Main Methods:

• Observational, retrospective, single-center study.
• Included 390 couples undergoing oocyte donation between 2005 and 2021.
• Analyzed reasons for program cessation.

Main Results:

• Nearly 80% of couples discontinued treatment without a live birth.
• Top reasons: treatment failure (18%), voluntary withdrawal (15%), separation (14%).
• 40% of couples achieved at least one live birth; 38 conceived spontaneously; 33 sought treatment abroad.

Conclusions:

• Treatment failure is the leading cause for discontinuing oocyte donation.
• A significant portion of couples achieve live births, indicating program effectiveness.
• Understanding reasons for discontinuation can optimize patient support and treatment strategies.