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Updated: Aug 23, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Leishmaniasis.

Gad Baneth¹, Laia Solano-Gallego²

¹The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, PO Box 12, Rehovot 7610001, Israel.

The Veterinary Clinics of North America. Small Animal Practice

|November 6, 2022

Summary

This summary is machine-generated.

Leishmaniasis in pets, caused by Leishmania infantum, is a widespread zoonotic disease. Treatment requires long-term medication, and relapses are common in infected dogs and cats.

Keywords:

Allopurinol Canine leishmaniasis Co-infection Feline leishmaniasis Leishmania infantum Meglumine antimoniate Miltefosine Topical insecticides

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In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

Area of Science:

Veterinary Medicine
Infectious Diseases
Parasitology

Background:

Leishmaniasis, caused by Leishmania infantum, is a significant zoonotic disease.
Sand flies are the vectors, leading to high infection rates in dogs and cats in endemic areas.
Clinical manifestations are systemic, affecting multiple organs with variable severity.

Purpose of the Study:

To summarize the key aspects of Leishmania infantum infection in companion animals.
To highlight the clinical presentation and treatment challenges of canine and feline leishmaniasis.

Main Methods:

Review of existing literature on Leishmania infantum in dogs and cats.
Analysis of clinical signs, diagnostic approaches, and therapeutic strategies.

Main Results:

Clinical findings in dogs and cats are generally similar, with frequent subclinical infections.
The disease affects skin, lymph nodes, eyes, bone marrow, and kidneys.
Long-term treatment is necessary, often involving allopurinol, meglumine antimoniate, or miltefosine.

Conclusions:

Leishmania infantum poses a considerable health risk to dogs and cats in endemic regions.
Effective long-term management is crucial due to the high probability of clinical relapse.
Understanding the disease's systemic nature and treatment complexities is vital for veterinary professionals.