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Correlation Between Low THBS3 Expression in Peripheral Blood and Acute Myocardial Infarction
Yanqiu Chen1,2,3,4,5, Heyu Meng1,2,3,4,5, Xin Meng1,2,3,4,5
1Department of Cardiology, China-Japan Union Hospital of Jilin University, 130033 Changchun, Jilin, China.
Frontiers in Bioscience (Landmark Edition)
|November 7, 2022
Summary
Low expression of Thrombospondin (THBS) 3 in peripheral blood may predict acute myocardial infarction (AMI) risk. This finding suggests THBS3 could serve as a novel biomarker for early AMI detection.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Molecular Biology
Background:
- Thrombospondin (THBS) 3 is a glycoprotein involved in cell interactions.
- Identifying reliable biomarkers for acute myocardial infarction (AMI) is crucial for early diagnosis and risk prediction.
- Peripheral blood biomarkers offer a minimally invasive approach for assessing cardiovascular disease risk.
Purpose of the Study:
- To investigate the potential of peripheral blood Thrombospondin (THBS) 3 expression as a predictive biomarker for acute myocardial infarction (AMI).
- To compare THBS3 levels in patients with stable coronary artery disease (SCAD) and those with AMI.
Main Methods:
- Peripheral blood samples were collected from 111 SCAD patients (control) and 112 AMI patients.
- Thrombospondin (THBS) 3 mRNA and protein levels were quantified using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively.
- Logistic regression analysis was employed to assess the association between THBS3 expression and AMI risk, considering other clinical factors.
Main Results:
- Peripheral plasma THBS3 protein levels were significantly lower in AMI patients compared to SCAD patients (0.82 times lower, p < 0.001).
- THBS3 mRNA levels in peripheral blood mononuclear cells were also reduced in AMI patients (0.47 times lower, p < 0.05).
- Decreased THBS3 protein expression was an independent risk factor for AMI, increasing probability by 4.076 times (p < 0.01).
- High fasting blood glucose and platelet counts were also associated with increased AMI risk.
Conclusions:
- Peripheral blood Thrombospondin (THBS) 3 (THBS3) mRNA and protein levels are significantly lower in patients with acute myocardial infarction (AMI) compared to those with stable coronary artery disease (SCAD).
- Low THBS3 expression is an independent risk factor for AMI.
- THBS3 in peripheral blood represents a potential novel and suitable molecular marker for the early detection of AMI.
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