Related Experiment Video

Updated: Aug 23, 2025

Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

7.4K

Impulse oscillometry (IOS) for detection of exercise induced bronchoconstriction in children with asthma ages 6-15

Samriti Gupta1,2, Aparna Mukherjee1,3, Sumita Gupta1

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|November 7, 2022
PubMed

Insights

Impulse oscillometry (IOS) can identify exercise-induced bronchoconstriction (EIB) in children with asthma. A 14.1% increase in R5 post-exercise is a useful indicator to rule out EIB.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Diagnostic Medicine

Background:

  • Exercise-induced bronchoconstriction (EIB) is common in children with asthma.
  • Accurate and accessible diagnostic tools are needed to identify EIB.
  • Impulse oscillometry (IOS) offers a non-invasive method to assess airway function.

Purpose of the Study:

  • To evaluate the discriminatory value of various IOS parameters for detecting EIB in children with asthma.
  • To establish a cutoff value for IOS parameters to identify EIB.
  • To assess the utility of IOS in diagnosing EIB in pediatric populations.

Main Methods:

  • A cross-sectional study involving 105 children (6-15 years) with asthma in India.
  • Pre- and post-exercise IOS and spirometry were performed following a standardized exercise challenge.
  • EIB was defined as a ≥10% decrease in FEV1 within 30 minutes post-exercise.

Main Results:

  • The prevalence of EIB was 20.95%.
  • The percentage change in R5 (respiratory resistance at 5 Hz) within 30 minutes post-exercise demonstrated the best discriminatory capacity (AUC 0.74).
  • A cutoff increase of 14.1% in R5 post-exercise showed high sensitivity (95.45%) and negative predictive value (97.67%) for EIB detection.

Conclusions:

  • A 14.1% increase in R5 post-exercise is the most effective IOS parameter for identifying EIB in children with asthma.
  • This cutoff value is particularly useful for ruling out EIB due to its high negative predictive value.
  • IOS provides a valuable tool for the diagnosis and management of EIB in pediatric asthma.
Abstract

Keywords:
EIBFEV1R5airway hyperresponsivenessearly detectionpost-exercise

More Related Videos

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.7K
Murine Model of Allergen Induced Asthma08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.4K

Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.8K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.8K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.6K
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.2K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
277