Graph Analysis of Functional Brain Topology Using Minimum Spanning Tree in Subjective Cognitive Decline

Area of Science:

• Neuroscience
• Neurology
• Psychiatry

Background:

• Subjective cognitive decline (SCD) is a potential early indicator for Alzheimer's disease (AD).
• Understanding the neuromechanisms of SCD is crucial for AD pathogenesis research.

Purpose of the Study:

• To investigate brain network topologies in individuals with SCD.
• To explore the neuromechanisms underlying SCD and its relationship with early AD indicators.

Main Methods:

• Resting-state BOLD-fMRI and clinical assessments were used on cognitively unimpaired subjects.
• Subjects were classified into SCD and normal control (NC) groups.
• Minimum spanning tree (MST) analysis explored brain network efficiency and centrality; hippocampal/parahippocampal volumes were measured.

Main Results:

• Brain network efficiency, centrality, and hippocampal/parahippocampal volumes were preserved in the SCD group.
• SCD individuals had normal cognitive functions but elevated levels of depression and anxiety.
• Language and execution, not memory, positively correlated with brain network centrality and hippocampal volume.

Conclusions:

• Subjective cognitive decline (SCD) is characterized by preserved brain organization efficiency and centrality.
• Clinical attention should be directed towards language, execution, depression, and anxiety in individuals with SCD.