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Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Related Experiment Video

Updated: Aug 23, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Coronary microvascular dysfunction is associated with impaired cognitive function: the Cerebral-Coronary Connection

Hernan Mejia-Renteria1, Alejandro Travieso1, Jordi A Matías-Guiu2

  • 1Interventional Cardiology Unit, Hospital Clinico San Carlos IdISSC, Universidad Complutense de Madrid, c/ Profesor Martín Lagos, s/n. 28240 Madrid, Spain.

European Heart Journal
|November 7, 2022
PubMed
Summary

Coronary microcirculatory dysfunction is common in coronary artery disease patients and linked to brain small vessel disease and cognitive decline, suggesting a shared microvascular pathology.

Keywords:
Cerebral small vessel diseaseCognitive impairmentCoronary microvascular dysfunctionIschaemic heart disease

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Area of Science:

  • Cardiology
  • Neurology
  • Vascular Biology

Background:

  • Coronary microcirculatory dysfunction (CMD) and cerebral small vessel disease (CSVD) are distinct conditions.
  • The relationship between CMD and CSVD, particularly in patients with coronary artery disease (CAD), remains unclear.

Purpose of the Study:

  • To investigate the prevalence of CMD in patients with CAD.
  • To assess the association between CMD, CSVD, and cognitive function in these patients.

Main Methods:

  • Prospective blinded study (C3) involving 67 CAD patients.
  • Physiological assessment of coronary microcirculation (coronary flow reserve - CFR).
  • Brain MRI, transcranial Doppler (TCD), and neurocognitive testing.

Main Results:

  • 55.2% of patients had abnormal CFR (<2.0).
  • Low CFR correlated with increased white-matter hyperintensities, reduced grey matter volume, and white-matter microstructural damage.
  • Low CFR was also associated with abnormal cerebral flow (TCD) and poorer cognitive test performance.

Conclusions:

  • CMD is prevalent in CAD patients and is associated with CSVD, impaired cerebral hemodynamics, and cognitive impairment.
  • These findings support a unified pathological process of microvascular dysfunction in both the heart and brain in CAD patients.