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Related Experiment Video

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Clarithromycin-Induced Visual Hallucinations.

Daragh McGee¹, Cathal Hanley², Audrey Reynolds²

¹Catherine McCauley Centre for Education, University College Dublin, Dublin, Republic of Ireland.

Neuro-Ophthalmology (Aeolus Press)

|November 7, 2022

Summary

A 90-year-old woman experienced visual hallucinations after starting clarithromycin. Symptoms resolved after stopping the antibiotic, suggesting a potential side effect.

Keywords:

Antibiotic clarithromycin visual hallucinations

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Area of Science:

Pharmacology
Neuroscience

Background:

A 90-year-old female patient with a history of cataract surgery presented with visual disturbances.
She was concurrently using sertraline and quinine.

Observation:

The patient developed vivid and dynamic visual hallucinations shortly after initiating clarithromycin.
Her visual acuity was otherwise normal.

Findings:

Symptoms completely resolved within 72 hours of discontinuing clarithromycin.
Clarithromycin may cause visual hallucinations by inhibiting GABA-ergic signaling, increasing neuronal excitability.

Implications:

This case highlights visual hallucinations as a potential adverse effect of clarithromycin.
Further research is needed to understand the neurobiological mechanisms of this side effect.