The objective of this manuscript is to analyze the socioeconomic and family characteristics of 50 years and older population who are at high risk of testing positive for Covid-19, being hospitalized or intubated in Mexico. We used two sources of information, the database of the Ministry of Health on Covid-19 and the Mexican Health and Aging Study in Mexico, in the first, regression models are estimated to calculate the risk and they are applied in the second to analyze socioeconomic and family vulnerabilities. Results show that gender and age are strong predictors of high risk. Those with less schooling, those who work without having a place, those who perceive their economic situation as fair or bad, as well as those who live in single-person households, receive financial and non-financial help from their children are presented as a highly vulnerable group to Covid-19 and its repercussions. It is necessary to develop strategies and support aimed to minimize the impacts of events such as the pandemic, ensure access to quality and timely health services, an economic income in accordance with the needs, and maintaining the standards of well-being of older adults.