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Bupropion-Induced Dystonia: A Case Report.

Tafseer Zahra¹, Diana Voloshyna², Anan Bseiso^3,4

¹Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

|November 7, 2022

Summary

Bupropion, an antidepressant and smoking cessation aid, can rarely cause acute facial dystonia, specifically involving the temporomandibular joint (TMJ). This side effect resolved quickly after discontinuing the medication.

Keywords:

antidepressant drug bupropion drug induced dystonia drug induced dystonia (did)dystonia

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Area of Science:

Neuroscience
Pharmacology
Clinical Medicine

Background:

Bupropion is a widely prescribed antidepressant known for its favorable sexual side effect profile compared to SSRIs.
It is also recognized for its efficacy in smoking cessation.
Common side effects include dizziness, anxiety, tremors, nausea, and insomnia.

Observation:

A case report details a 54-year-old chronic smoker experiencing acute facial dystonia affecting the temporomandibular joint (TMJ).
This adverse event occurred after the patient was prescribed 300 mg of bupropion.
The Naranjo scale was utilized to evaluate the likelihood of bupropion-induced dystonia.

Findings:

The patient's acute facial dystonia completely resolved within one week of discontinuing bupropion.
No recurrence of dystonia was observed during subsequent follow-up appointments.
This suggests a direct causal link between bupropion and the observed dystonia.

Implications:

This case highlights a rare but significant neurological side effect of bupropion, specifically dystonia.
Physicians should be aware of this potential adverse reaction, especially in patients with risk factors.
Prompt recognition and discontinuation of bupropion can lead to complete resolution of TMJ-related dystonia.