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Bispecific T cell engagers kill resistant cells during KRAS-G12C blockade therapy
Xinxin Song1, Zhuan Zhou1, Rui Kang1
1Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA.
None:
The covalent KRAS-G12C inhibitors (G12Ci) are rapidly changing the treatment landscape for advanced non-small cell lung cancer, but drug resistance remains a clinical challenge. Two recent studies have developed bispecific T cell engagers that form a link between T cells and tumor cells to selectively eliminate G12Ci-resistant cells.
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