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Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels

Ki-Bum Won1,2,3, Byoung Kwon Lee4, Ran Heo3,5

  • 1Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang, South Korea.

JACC. Asia
|November 7, 2022
PubMed

Insights

Changes in serum hemoglobin levels independently affect coronary atherosclerosis progression. This impact is more pronounced in individuals with lower baseline hemoglobin, as shown by serial coronary computed tomographic angiography.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Radiology

Background:

  • Hemoglobin's role in atherosclerosis is under-investigated, with limited data on its impact on coronary plaque volume changes.
  • Understanding this relationship is crucial for managing cardiovascular disease risk.

Purpose of the Study:

  • To evaluate the association between serum hemoglobin level changes and coronary atherosclerotic plaque burden progression.
  • Utilizing serial coronary computed tomographic angiography (CCTA) to quantify plaque volume changes.

Main Methods:

  • Analysis of 830 subjects undergoing serial CCTA over a median of 3.2 years.
  • Stratification into four groups based on baseline hemoglobin quartiles.
  • Quantitative assessment of coronary plaque volume and calculation of annualized plaque volume change (PVC).

Main Results:

  • No significant difference in baseline plaque volume across hemoglobin groups.
  • Changes in hemoglobin levels (Δ hemoglobin) were associated with annualized total PVC in the overall cohort (P < 0.05).
  • Adjusted analysis revealed that Δ hemoglobin significantly impacted annualized total PVC in participants with lower baseline hemoglobin levels (groups I and II, P = 0.004).

Conclusions:

  • Serial CCTA findings indicate that changes in hemoglobin levels have an independent effect on coronary atherosclerosis progression.
  • The influence of hemoglobin changes on plaque progression may be modulated by baseline hemoglobin levels.
Abstract

Keywords:
CCTA, coronary computed tomographic angiographyCV, cardiovascularPVC, plaque volume changesatherosclerosiscoronary computed tomography angiographyhemoglobinΔ hemoglobin, hemoglobin level changes

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