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Role of Sostdc1 in skeletal biology and cancer

Xiaoyang Tong1, Chenyu Zhu1, Lifei Liu2

  • 1School of Exercise and Health, Shanghai University of Sport, Shanghai, China.

Frontiers in Physiology
|November 7, 2022
PubMed

Insights

Sclerostin domain-containing protein-1 (Sostdc1) regulates bone metabolism and Wnt signaling. This protein is crucial in skeletal biology and linked to various cancers, offering therapeutic insights.

Area of Science:

  • Molecular Biology
  • Skeletal Biology
  • Oncology

Background:

  • Sclerostin domain-containing protein-1 (Sostdc1) is a secreted protein in the sclerostin family.
  • Sostdc1 acts as an antagonist to bone morphogenetic protein (BMP) and interacts with LRP6, modulating BMP and Wnt signaling pathways.
  • It influences cellular processes like proliferation, differentiation, and apoptosis across various tissues.

Purpose of the Study:

  • To summarize the multifaceted roles of Sostdc1 in skeletal biology.
  • To review the association between Sostdc1 and the development and progression of multiple cancer types.
  • To provide a theoretical foundation for Sostdc1-targeted disease treatments.

Main Methods:

  • Literature review and synthesis of existing research on Sostdc1.
  • Analysis of Sostdc1's function in bone metabolism, density, and fracture healing.
  • Examination of Sostdc1's involvement in breast, renal, gastric, and thyroid cancers.

Main Results:

  • Sostdc1 is essential for maintaining bone metabolism, bone density, and fracture healing.
  • Sostdc1 plays a significant role in various physiological processes and has been implicated in Alport syndrome.
  • Emerging evidence links Sostdc1 to the pathogenesis of several cancers, including breast, renal, gastric, and thyroid malignancies.

Conclusions:

  • Sostdc1 is a key regulator in skeletal biology with implications for bone health.
  • The protein's involvement in cancer development highlights its potential as a therapeutic target.
  • Further research into Sostdc1's functions can inform novel treatment strategies for skeletal disorders and cancers.
Keywords:
BMPSOSTDC1Wntcancerskeletal biology

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