Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C3 and Bf complement types in chronic renal failure.

S S Papiha, R S Rodger

    Human Genetics
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genomic probes in prenatal diagnosis of duchenne muscular dystrophy in Indians and Chinese.

    The National medical journal of India·2018
    Same author

    Khmers of Cambodia: A comparative genetic study of the populations of Southeast Asia.

    American journal of human biology : the official journal of the Human Biology Council·2017
    Same author

    Tacrolimus combined with two different dosages of sirolimus in kidney transplantation: results of a multicenter study.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006
    Same author

    The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations.

    American journal of human genetics·2003
    Same author

    An unidentified hepatitis B virus carrier on a haemodialysis unit: management and outcome.

    The Journal of hospital infection·2001
    Same author

    D1S80 distribution in world populations with new data from the UK and the Indian sub-continent.

    Annals of human biology·2001
    Same journal

    AI in variant analysis: fast track to genetic diagnoses.

    Human genetics·2026
    Same journal

    Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder.

    Human genetics·2026
    Same journal

    Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.

    Human genetics·2026
    Same journal

    ARHI as a key regulator of EMT and metastasis in pancreatic cancer via the Notch-1 pathway.

    Human genetics·2026
    Same journal

    Large-scale mitogenome analysis reveals complex maternal genetic connections between Sino-Tibetan- and Altaic-speaking populations.

    Human genetics·2026
    Same journal

    Correction: A comprehensive and accessible model for co-segregation analysis in BRCA1, BRCA2, and PALB2 variant classification.

    Human genetics·2026
    See all related articles

    The C3*S allele was significantly increased in idiopathic membranous nephropathy (IMN) patients who progressed to renal failure. This finding may offer insights into the disease

    Area of Science:

    • Immunogenetics
    • Nephrology
    • Complement System Biology

    Background:

    • Idiopathic membranous nephropathy (IMN) is a leading cause of nephrotic syndrome in adults.
    • The complement system, particularly the alternative pathway involving C3 and Factor B (BF), plays a crucial role in IMN pathogenesis.
    • Genetic variations in complement genes may influence disease susceptibility and progression.

    Purpose of the Study:

    • To investigate the association between C3 and BF allele frequencies and the progression of idiopathic membranous nephropathy (IMN).
    • To identify potential genetic markers for renal failure in IMN patients.

    Main Methods:

    • Case-control study design.
    • Analysis of C3 and BF allele frequencies in 55 IMN patients and healthy controls from North-East England.

    Related Experiment Videos

  • Comparison of allele frequencies between IMN patients who progressed to renal failure and those who did not.

    • Main Results:

    • A significant increase in the C3*S allele frequency was observed in IMN patients who progressed to renal failure compared to those who did not.
    • No significant differences were noted for other studied alleles.

    Conclusions:

    • The C3*S allele may be associated with a poorer prognosis and progression to renal failure in idiopathic membranous nephropathy.
    • Further research into the functional mechanisms linking C3*S allele and IMN progression is warranted.