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Updated: Aug 22, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma

Huimin Lei1, Ading He1, Yingying Jiang1

  • 1School of Stomatology, Weifang Medical University, Weifang, China.

Frontiers in Oncology
|November 7, 2022
PubMed

Insights

DNA damage response (DDR) pathways are crucial for genome integrity. Targeting DDR defects offers a promising therapeutic strategy for head and neck squamous cell carcinoma (HNSCC) treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Cells constantly face DNA damage from internal and external sources.
  • The DNA damage response (DDR) is essential for repairing DNA and maintaining genome stability.
  • Defects in DDR pathways are linked to various diseases, including cancer.

Purpose of the Study:

  • To review DNA damage sources and repair pathways.
  • To elucidate the role of DDR in head and neck squamous cell carcinoma (HNSCC) development.
  • To explore the therapeutic potential of targeting DDR in HNSCC.

Main Methods:

  • Literature review of DNA damage and repair mechanisms.
  • Analysis of DDR gene alterations (mutations, SNPs, methylation) in HNSCC.
  • Examination of small molecule inhibitors targeting DDR pathways.

Main Results:

  • Alterations in DDR genes are associated with HNSCC occurrence, progression, and treatment response.
  • Current HNSCC treatments show limited survival improvement.
  • Targeting DDR pathways presents a potential therapeutic avenue for HNSCC.

Conclusions:

  • Understanding DDR pathways is critical for HNSCC research.
  • Targeting DDR offers a promising strategy to improve HNSCC patient outcomes.
  • Further investigation into DDR inhibitors is warranted for HNSCC therapy.
Keywords:
ATR and ATM inhibitorDNA damage response (DDR)DNA-PK inhibitorPARP1 inhibitorWEE1 inhibitorhead and neck squamous cell carcinoma (HNSCC)

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