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The roles of BTG1 mRNA expression in cancers: A bioinformatics analysis

Hua-Chuan Zheng1, Hang Xue1, Cong-Yu Zhang2

  • 1Department of Oncology, The Affiliated Hospital of Chengde Medical University, Chengde, China.

Frontiers in Genetics
|November 7, 2022
PubMed

Insights

B-cell translocation gene 1 (BTG1) mRNA is often downregulated in cancers like gastric, lung, breast, and ovarian cancers. Its expression correlates with tumor progression and can serve as a prognostic marker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • B-cell translocation gene 1 (BTG1) is known to inhibit proliferation and cell cycle progression.
  • Understanding BTG1's role in various cancers is crucial for developing new therapeutic strategies.
  • Investigating BTG1 mRNA expression and its associated signaling pathways can reveal insights into cancer development and prognosis.

Purpose of the Study:

  • To elucidate the clinicopathological and prognostic significance of BTG1 mRNA expression in human cancers.
  • To analyze the relationship between BTG1 expression and key signaling pathways across different cancer types.

Main Methods:

  • Utilized bioinformatics databases including Oncomine, TCGA, xiantao, UALCAN, and Kaplan-Meier plotter.
  • Analyzed BTG1 mRNA expression levels in various cancers compared to normal tissues.
  • Correlated BTG1 expression with clinicopathological features and patient prognosis.
  • Performed Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and identified hub genes.

Main Results:

  • BTG1 mRNA expression was significantly lower in gastric, lung, breast, and ovarian cancers, often due to promoter methylation.
  • BTG1 expression correlated with tumor dedifferentiation, grading, subtype, and patient demographics across different cancers.
  • BTG1 expression was negatively associated with favorable prognosis in gastric, lung, and ovarian cancers, but positively in breast cancer.
  • Key signaling pathways identified include cytokine-cytokine receptor interaction, cell adhesion molecules, and NF-κB signaling.

Conclusions:

  • BTG1 mRNA expression is altered in multiple cancers and is linked to clinicopathological features and patient outcomes.
  • BTG1 may serve as a potential biomarker for cancer carcinogenesis, progression, and prognosis.
  • Further research into BTG1 and its associated pathways could lead to novel cancer diagnostics and therapeutics.
Keywords:
Btg1aggressivenessbioinformatics analysiscarcinogenesisprognosis

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