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A binocular perception deficit characterizes prey pursuit in developing mice.

Kelsey Allen1, Rocio Gonzalez-Olvera1, Milen Kumar1

  • 1Department of Biology, University of Nevada, Reno, Reno, NV 89557, USA.

Iscience
|November 7, 2022
PubMed
Summary
This summary is machine-generated.

Developing mice (P21) show binocular visual field deficits, unlike adults. This links impaired binocular perception in juveniles to altered activity in the superior colliculus (SC) during visual tasks.

Keywords:
Biological sciencesNeuroscienceSensory neuroscience

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Vision Science

Background:

  • Cellular mechanisms of binocular integration in mammalian vision are well-studied in mice.
  • The developmental timeline of visually guided behaviors relying on binocular input remains poorly understood.

Purpose of the Study:

  • To investigate the ontogeny of binocular visual processing and behavior in mice.
  • To correlate developmental visual deficits with neural activity patterns.

Main Methods:

  • Quantified visually guided behaviors in postnatal day 21 (P21) mice and adult mice.
  • Utilized a live prey capture assay and a computerized-spontaneous perception of objects task (C-SPOT).
  • Measured neural activity via c-Fos expression in the anterior superior colliculus (SC).

Main Results:

  • P21 mice exhibited a specific deficit in binocular visual field processing compared to adults.
  • Juvenile mice showed increased c-Fos expression in the anterior SC after the C-SPOT task.
  • This neural activity change correlated with the observed binocular perception deficit.

Conclusions:

  • A specific binocular perception deficit exists in developing mice.
  • This deficit is linked to altered neural activity in the superior colliculus during a critical developmental period.
  • Provides insight into the developmental trajectory of binocular vision in mammals.