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Published on: January 28, 2020
Soluble Corin Predicts the Risk of Cardiovascular Disease: A 10-Year Follow-Up Study
Linan Chen1, Qiu Zhang2, Min Zhang3
1Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Insights
Higher levels of serum corin, an enzyme in the natriuretic peptides system, predict increased risk of cardiovascular disease (CVD) and stroke in Chinese adults. This finding suggests corin may serve as a novel biomarker for stroke prediction.
Area of Science:
- Biochemistry
- Cardiology
- Epidemiology
Background:
- Corin, a key enzyme in the natriuretic peptides system, is implicated in cardiovascular disease (CVD) development.
- Circulating corin levels have predicted CVD recurrence in specific patient groups, but its predictive value in the general population remained unexamined.
Purpose of the Study:
- To investigate the prospective association between serum corin levels and the incidence of CVD in a community-based cohort of Chinese adults.
Main Methods:
- The Gusu cohort study enrolled 2,498 participants free of CVD at baseline.
- Serum corin was quantified using ELISA, and participants were followed for CVD events over 10 years.
- Competing-risks survival regression models analyzed the association between serum corin and CVD risk.
Main Results:
- A higher baseline serum corin level was significantly associated with an increased risk of CVD (HR: 1.88) and stroke (HR: 3.19).
- Participants in the highest quartile of serum corin exhibited a 62% increased risk for CVD and a 179% increased risk for stroke compared to the lowest quartile.
- No significant association was found between serum corin levels and coronary heart disease risk.
Conclusions:
- Elevated serum corin levels at baseline predict a higher risk of incident CVD and stroke in Chinese adults, independent of traditional risk factors.
- Serum corin may serve as a potential biomarker for predicting stroke risk, although further research is needed to elucidate the underlying mechanisms.
Background:
As a key enzyme of the natriuretic peptides system, corin may participate in the development of cardiovascular disease (CVD). Its level in circulation predicted CVD recurrence in patients with myocardial infarction and heart failure, but no study examined this prediction in general populations.
Objectives:
This study sought to examine the prospective association between corin and CVD in a community-based population of Chinese adults.
Methods:
The Gusu cohort included 2,498 participants (mean age 53 years, 39% men) who were free of CVD at baseline. Serum corin was measured by enzyme-linked immunosorbent assay kits at baseline and CVD events were followed every 2 years for all participants. A competing-risks survival regression model was used to examine the association between serum corin and CVD.
Results:
During 10 years of follow-up, 210 participants developed CVD including 88 stroke events. A higher serum corin (after log-transformation) at baseline was significantly associated with an increased risk of CVD (HR: 1.88; P = 0.019) and stroke (HR: 3.19; P = 0.014). Analysis using categorical serum corin (in quartiles) showed that participants in the highest quartile had a 62% and 179% increased risk for CVD (HR: 1.62; P = 0.024) and stroke (HR: 2.79; P = 0.004), respectively, compared with those in the lowest quartile. We did not find a significant association between serum corin and coronary heart disease.
Conclusions:
A higher serum corin at baseline predicted a higher risk of CVD events and stroke, but not coronary heart disease, in Chinese adults, independent of conventional risk factors. Serum corin may be a predictor for stroke but the underlying mechanism needs further investigation.
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