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Published on: January 14, 2011
Resveratrol activates CD8+ T cells through IL-18 bystander activation in lung adenocarcinoma
Wei Zhang1, Ruohao Zhang2, Zhiguang Chang3
1Emergency and Disaster Medical Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Abstract:
Resveratrol, a natural product, has demonstrated anti-tumor effects in various kinds of tumor types, including colon, breast, and pancreatic cancers. Most research has focused on the inhibitory effects of resveratrol on tumor cells themselves rather than resveratrol's effects on tumor immunology. In this study, we found that resveratrol inhibited the growth of lung adenocarcinoma in a subcutaneous tumor model by using the β-cyclodextrin-resveratrol inclusion complex. After resveratrol treatment, the proportion of M2-like tumor-associated macrophages (TAMs) was reduced and tumor-infiltrating CD8T cells showed significantly increased activation. The results of co-culture and antibody neutralization experiments suggested that macrophage-derived IL-18 may be a key cytokine in the resveratrol anti-tumor effect of CD8T cell activation. The results of this study demonstrate a novel view of the mechanisms of resveratrol tumor suppression. This natural product could reprogram TAMs and CD8T effector cells for tumor treatment.
Insights
Resveratrol, a natural compound, effectively inhibits lung adenocarcinoma growth by reprogramming tumor immunology. It reduces M2-like macrophages and enhances CD8T cell activation, offering a novel cancer treatment strategy.
Area of Science:
- Immunology
- Oncology
- Natural Products Chemistry
Background:
- Resveratrol exhibits anti-tumor properties across various cancers.
- Limited research explores resveratrol's impact on tumor immunology.
- Understanding its immunomodulatory effects is crucial for cancer therapy.
Purpose of the Study:
- To investigate resveratrol's anti-tumor mechanisms in lung adenocarcinoma.
- To explore resveratrol's effects on tumor-associated macrophages (TAMs) and CD8T cells.
- To identify key cytokines involved in resveratrol's anti-tumor immune response.
Main Methods:
- Utilized a subcutaneous lung adenocarcinoma tumor model with a β-cyclodextrin-resveratrol complex.
- Analyzed changes in M2-like TAMs and CD8T cell activation post-resveratrol treatment.
- Performed co-culture and antibody neutralization experiments to assess cytokine roles.
Main Results:
- Resveratrol inhibited tumor growth in the lung adenocarcinoma model.
- Reduced proportion of M2-like TAMs and increased CD8T cell activation observed.
- Macrophage-derived IL-18 identified as a key cytokine for CD8T cell activation.
Conclusions:
- Resveratrol demonstrates anti-tumor effects by modulating tumor immunology.
- Resveratrol can reprogram TAMs and enhance CD8T effector cell activity.
- This study provides novel insights into resveratrol's cancer-suppressive mechanisms.
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