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ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology

Timothy J Mead1,2

  • 1Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, United States.

Frontiers in Molecular Biosciences
|November 7, 2022
PubMed

Insights

ADAMTS6 (a disintegrin and metalloproteinase with thrombospondin motifs 6) is crucial for cardiovascular and musculoskeletal development. This proteinase also plays a role in various diseases, including cancer, warranting further study.

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Molecular Biology

Background:

  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases regulate extracellular matrix composition, impacting mammalian development and disease.
  • ADAMTS6 was previously considered an orphan proteinase with poorly understood expression and function within the ADAMTS family.
  • Recent research highlights the significant role of ADAMTS6 in cardiovascular and musculoskeletal development.

Purpose of the Study:

  • To review the essential functions of ADAMTS6 during mammalian development.
  • To summarize the involvement of ADAMTS6 in various disease pathologies, including cancer.
  • To underscore the need for further research into ADAMTS6's biological implications and therapeutic potential.

Main Methods:

  • Literature review of existing studies on ADAMTS6.
  • Analysis of expression patterns and functional data for ADAMTS6.
  • Synthesis of information regarding ADAMTS6's role in development and disease.

Main Results:

  • ADAMTS6 is indispensable for proper cardiovascular and musculoskeletal development.
  • ADAMTS6 is implicated in the pathogenesis of several diseases, notably various cancers.
  • The expression and precise functions of ADAMTS6 are increasingly being elucidated.

Conclusions:

  • ADAMTS6 is a key regulator in developmental processes.
  • Dysregulation of ADAMTS6 is associated with significant disease states.
  • Further investigation is required to fully understand ADAMTS6's biological roles and harness its therapeutic potential.
Keywords:
ADAMTS6cancercardiovascularextracellular matrixmatrix metalloproteasemusculoskeletal

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