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Updated: Aug 22, 2025

Studying Mitochondrial Structure and Function in Drosophila Ovaries
Published on: January 4, 2017
Mitochondrial dynamics involves molecular and mechanical events in motility, fusion and fission
Adam Green1, Tanvir Hossain1, David M Eckmann1,2
1Department of Anesthesiology, The Ohio State University, Columbus, OH, United States.
Abstract:
Mitochondria are cell organelles that play pivotal roles in maintaining cell survival, cellular metabolic homeostasis, and cell death. Mitochondria are highly dynamic entities which undergo fusion and fission, and have been shown to be very motile in vivo in neurons and in vitro in multiple cell lines. Fusion and fission are essential for maintaining mitochondrial homeostasis through control of morphology, content exchange, inheritance of mitochondria, maintenance of mitochondrial DNA, and removal of damaged mitochondria by autophagy. Mitochondrial motility occurs through mechanical and molecular mechanisms which translocate mitochondria to sites of high energy demand. Motility also plays an important role in intracellular signaling. Here, we review key features that mediate mitochondrial dynamics and explore methods to advance the study of mitochondrial motility as well as mitochondrial dynamics-related diseases and mitochondrial-targeted therapeutics.
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