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Related Experiment Video

Updated: Aug 22, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Published on: June 7, 2015

An automated controlled-release device for intravaginal hormone delivery.

M Masello¹, Y Ren², D Erickson²

¹Department of Animal Science, Cornell University, Ithaca, NY 14853.

JDS Communications

|November 7, 2022

Summary

A new intravaginal (IVG) device automates prostaglandin F2α (PGF2α) delivery for cattle reproductive control. This technology successfully induced luteal regression in dairy cows, showing potential for improved herd management.

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Area of Science:

Veterinary Science
Reproductive Endocrinology
Biomedical Engineering

Background:

Accurate hormone delivery is crucial for cattle reproductive management.
Existing methods for inducing luteal regression can be labor-intensive.
Automated delivery systems offer potential for improved precision and efficiency.

Purpose of the Study:

To develop and validate an electronically controlled intravaginal (IVG) hormone-delivery device.
To assess the device's ability to automate prostaglandin F2α (PGF2α) release for luteal regression.
To evaluate the in vivo efficacy of the IVG device in lactating dairy cows.

Main Methods:

Developed a 3D-printed IVG device with programmable pumps and reservoirs.
Conducted in vitro testing to validate hormone release accuracy.
Performed in vivo study in lactating Holstein cows, comparing IVG PGF2α delivery to intramuscular PGF2α and a placebo control.

Main Results:

In vitro tests showed excellent agreement between programmed and delivered PGF2α volumes.
All implanted IVG devices remained in situ throughout the study.
Automated IVG PGF2α delivery effectively reduced progesterone concentrations, similar to intramuscular administration, indicating successful luteal regression.

Conclusions:

The developed IVG device accurately releases hormones in vitro.
The automated IVG PGF2α delivery system successfully induced luteal regression in dairy cows.
This technology represents a promising advancement for precise reproductive control in cattle.