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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

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Mirabegron Associated Angioedema: A Case Report.

Matthew T Zuchowski^1,2, Jaylan M Yuksel¹, John Novi¹

¹Upstate Community Hospital, Syracuse NY, USA.

Hospital Pharmacy

|November 7, 2022

Summary

A woman experienced tongue angioedema, a rare side effect of mirabegron, after years of use. Symptoms resolved after discontinuing the medication and receiving treatment.

Keywords:

angioedema mirabegron tongue

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Published on: May 11, 2011

Area of Science:

Pharmacology
Adverse Drug Reactions
Allergy and Immunology

Background:

Mirabegron is a beta-3 adrenergic agonist used for overactive bladder.
Angioedema is a known, albeit rare, adverse effect of some medications.
This case highlights a potential link between mirabegron and angioedema.

Observation:

A 77-year-old female developed sudden onset tongue swelling.
She was taking multiple medications, including mirabegron for 3-4 years.
Symptoms began while self-tapering mirabegron dosage.

Findings:

The patient was diagnosed with drug-induced angioedema.
Mirabegron was identified as the probable cause using the Naranjo scale.
Symptoms improved with standard angioedema treatment and mirabegron discontinuation.

Implications:

This case adds to the limited reports of mirabegron-induced angioedema.
Healthcare providers should consider mirabegron as a potential cause of angioedema, even after long-term use.
Further investigation into the mechanism of mirabegron-induced angioedema may be warranted.