Related Experiment Video
Updated: Aug 22, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Systematic review on the prevalence of perinatal depression in Malawi
Genesis Chorwe-Sungani1, Kondwani Wella2, Patrick Mapulanga2
1Department of Mental Health, School of Nursing, Kamuzu University of Health Sciences, Blantyre, Malawi.
Background:
Perinatal depression causes significant burden to women and their families during the perinatal period. However, there is no reliable national prevalence data on perinatal depression in Malawi.
Aim:
This systematic review aimed at establishing the pooled prevalence of perinatal depression.
Setting:
The study setting is Malawi.
Methods:
Two reviewers conducted the search, selection, quality evaluation and data abstraction. Appropriate terms were used to search the CINAHL, PsychINFO, PubMed and ScienceDirect databases. The relevance and the quality of the studies were assessed. The prevalence of prenatal depression was pooled using a random-effects model, which was used to synthesise the data.
Results:
The review included a total of eight articles of fair and good quality. This review found a pooled prevalence of antenatal depression of 17.1% (95.0% confidence interval [CI]: 12.5-22.2) and postnatal depression of 19.8% (95.0% CI: 4.6-42.1) with an overall pooled prevalence of perinatal depression of 18.9% (95.0% CI: 14.5-23.8).
Conclusion:
This systematic review provided a pooled prevalence of perinatal depression which may be used in the absence of national prevalence data on perinatal depression.
Contribution:
This systematic review found a high a pooled prevalence of perinatal depression in Malawi suggesting that mental health should be a key component of maternal health programmes, policies and activities in the local setting.
More Related Videos
Related Concept Videos
Long-term Depression
Depression: Overview
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

