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Non-invasive brain neuromodulation techniques for chronic low back pain
Tian-Tian Chang1, Yu-Hao Chang2, Shu-Hao Du1
1Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Frontiers in Molecular Neuroscience
|November 7, 2022
Summary
Non-invasive brain neuromodulation (NIBS) shows promise for treating chronic low back pain (CLBP). Further high-quality studies are needed to confirm its effectiveness and understand its mechanisms for CLBP management.
Area of Science:
- Neuroscience
- Pain Management
- Neuromodulation
Background:
- Chronic low back pain (CLBP) is associated with brain structural and functional changes.
- Effective treatments can reverse these brain abnormalities.
- Clinical applications of non-invasive brain neuromodulation (NIBS) for chronic pain are growing.
Purpose of the Study:
- To review the effectiveness and limitations of NIBS techniques for CLBP management.
- To describe the effects and mechanisms of NIBS on CLBP.
Main Methods:
- Systematic review of existing literature on NIBS for CLBP.
- Analysis of studies on the clinical applications and mechanisms of NIBS in CLBP.
Main Results:
- NIBS may be effective for treating CLBP.
- Potential analgesic mechanisms include regulating pain pathways, synaptic plasticity, neuroprotection, neuroinflammation, and cerebral blood flow/metabolism.
- Current studies are limited by small sample sizes, low evidence quality, and lack of mechanistic investigations.
Conclusions:
- NIBS holds potential for CLBP treatment.
- Further high-quality randomized controlled trials with large sample sizes are necessary to validate effectiveness and elucidate mechanisms.
