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The Relationship between Uric Acid and the Development, Complication, and Prognosis of Atrial Fibrillation: The Views

Jian Yang1, Lian Lou1, Xuan Zhang1

  • 1Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

International Journal of Endocrinology
|November 7, 2022
PubMed

Insights

Uric acid (UA) is linked to atrial fibrillation (AF) occurrence and complications, but its role in AF management needs more research. UA-lowering therapy

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Research

Background:

  • Numerous studies indicate a relationship between uric acid (UA) and the incidence, complications, and prognosis of atrial fibrillation (AF).
  • Current clinical guidelines lack clear recommendations regarding the management of uric acid in AF patients.
  • Existing research predominantly focuses on the association between UA and AF development or complications, with limited exploration of therapeutic interventions.

Purpose of the Study:

  • To summarize current research on the association between uric acid and atrial fibrillation.
  • To identify gaps in the understanding of uric acid's role in AF management.
  • To highlight the need for further investigation into UA-lowering therapies for AF.

Main Methods:

  • Systematic review and analysis of existing clinical research on uric acid and atrial fibrillation.
  • Evaluation of studies focusing on the development and complications of AF in relation to UA levels.
  • Assessment of the limited available data on the impact of UA-lowering therapy on AF management.

Main Results:

  • Current research primarily concentrates on the link between UA and AF development/complications, leading to repetitive findings.
  • Studies investigating the efficacy of UA-lowering therapy in AF management are scarce.
  • Existing evidence suggests UA-lowering therapy may not offer a protective effect against AF.

Conclusions:

  • Uric acid is closely associated with the occurrence and progression of atrial fibrillation, suggesting its potential as a clinical marker.
  • The role of UA-lowering therapy in AF management remains an underexplored area requiring significant future research.
  • Further investigation, including secondary analysis of AF ablation data and multiomics approaches, is warranted to elucidate UA's prognostic impact and role in AF management.

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