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Related Concept Videos

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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Related Experiment Video

Updated: Aug 22, 2025

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
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The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

Jody S Nicholson1, Elizabeth M Hudak2, Christine B Phillips3

  • 1Department of Psychology, University of North Florida, 1 UNF Dr, Jacksonville, FL 32224, United States.

Contemporary Clinical Trials
|November 7, 2022
PubMed
Summary

This study tested computerized cognitive training (UFOVT) to prevent dementia and mild cognitive impairment (MCI) in older adults. Results will inform non-pharmaceutical dementia prevention strategies.

Keywords:
AgingAlzheimer's diseaseBlood biomarkersDementiaUseful field of view training

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Alzheimer's disease and related dementias (ADRD) prevalence is rising globally.
  • Effective, widely disseminable interventions are needed for ADRD prevention.
  • Computerized cognitive training offers a potential non-pharmaceutical approach.

Purpose of the Study:

  • To evaluate the effectiveness of Useful Field of View Training (UFOVT) in reducing the incidence of mild cognitive impairment (MCI) or dementia.
  • To investigate if plasma β-amyloid levels or apolipoprotein E ε4 (APOE ε4) allele status moderate UFOVT effects.
  • To assess the impact of cognitive training on cognitive decline in older adults.

Main Methods:

  • Multisite randomized controlled trial with blinded assessors and investigators.
  • Community-recruited individuals aged 65+ with intact cognition (Montreal Cognitive Assessment score > 25).
  • Participants completed 45 sessions of UFOVT or computerized games over 2.5 years, followed by 3 years of monitoring and clinical/neuropsychological assessments.

Main Results:

  • Data collection and analysis are ongoing.
  • The study aims to determine if UFOVT reduces MCI or dementia incidence.
  • Biomarker analysis (β-amyloid, APOE ε4) will explore potential moderators of treatment effects.

Conclusions:

  • The Preventing Alzheimer's with Cognitive Training (PACT) study addresses the urgent need for dementia prevention strategies.
  • Computerized cognitive training, specifically UFOVT, may offer a scalable solution to mitigate the public health burden of dementia.
  • Findings will contribute to evidence-based non-pharmacological interventions for cognitive health in aging populations.