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Related Experiment Video

Updated: Aug 22, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Glucose-responsive nanoparticles designed via a molecular-docking-driven method for insulin delivery.

Di Shen¹, Haojie Yu¹, Li Wang¹

¹State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|November 7, 2022

Summary

Researchers developed smart, glucose-responsive insulin nanoparticles for better diabetic treatment. The novel formulation effectively controlled nocturnal blood glucose in rats, reducing hypoglycemia risk compared to traditional methods.

Keywords:

Anti-hypoglycemia properties Diabetes Glucose-responsive nanoparticles Insulin delivery Molecular docking

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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An In Ovo Model for Testing Insulin-mimetic Compounds

An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology
Diabetic Treatment

Background:

Nocturnal blood glucose regulation presents a significant challenge in diabetes management.
Current smart insulin delivery systems often rely on extensive empirical testing and researcher experience.
Developing glucose-responsive systems with mild and effective performance is crucial for improved patient outcomes.

Purpose of the Study:

To design and synthesize bioinspired, fatty-acid-modified, glucose-responsive polymeric nanoparticles for insulin delivery.
To utilize molecular docking for efficient screening of functional groups in polymer design.
To evaluate the efficacy and safety of the optimized nanoparticles in a preclinical model.

Main Methods:

Design of fatty-acid-modified glucose-responsive polymeric nanoparticles.
Application of molecular docking to screen functional groups for polymer modification.
In vivo evaluation of insulin-loaded nanoparticles (C10MS) in diabetic rats for nocturnal glycemic control.
Assessment of biocompatibility and pharmacokinetic profiles.

Main Results:

The optimized formulation (C10MS) demonstrated successful nocturnal glycemic control in diabetic rats.
The C10MS formulation exhibited a lower incidence of hypoglycemia compared to conventional insulin injections.
The nanoparticles showed good biocompatibility and moderate in vivo elimination kinetics, suitable for daily treatment.

Conclusions:

This study presents an efficient, experience-guided approach for designing functional polymeric materials for smart drug delivery.
Bioinspired fatty-acid-modified nanoparticles offer a promising strategy for improved diabetes management, particularly for nocturnal glucose regulation.
The developed system simplifies the optimization process for glucose-responsive insulin delivery systems.