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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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Immune repertoire profiling for disease pathobiology.

Hiroto Katoh1, Daisuke Komura1, Genta Furuya1

  • 1Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Pathology International
|November 7, 2022
PubMed
Summary

Immune repertoire sequencing analyzes T and B cell receptors to understand disease mechanisms. This powerful technique aids in discovering new therapies for various human diseases.

Keywords:
adaptive immunityimmune repertoire sequencingimmunoglobulin repertoire

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Area of Science:

  • Immunology
  • Genomics
  • Pathology

Background:

  • Lymphocytes are key immune cells involved in diverse diseases, from autoimmune conditions to cancers.
  • Understanding lymphocyte heterogeneity is crucial for disease research.
  • Immune repertoire sequencing offers a global view of immune cell receptor sequences.

Purpose of the Study:

  • To review the background and methodology of immune repertoire sequencing.
  • To summarize recent advancements linking immune repertoire sequencing to human diseases.
  • To discuss future applications of this technique in histopathological research.

Main Methods:

  • Immune repertoire sequencing.
  • Analysis of T cell and B cell receptor sequences.
  • Review of existing scientific literature.

Main Results:

  • Immune repertoire sequencing provides global profiles of immune receptors in specimens.
  • This technique deepens understanding of immune-related pathology.
  • It assists in the discovery of novel therapeutic strategies.

Conclusions:

  • Immune repertoire sequencing is a valuable tool for understanding disease.
  • It holds promise for developing new treatments.
  • Future applications in histopathology are anticipated.