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Iris Color Matters-A Contractility Analysis With Dynamic Volume-Rendered Optical Coherence Tomography Pupillometry
Philippe Valmaggia1,2, Nadja Inglin1, Pascal Kaiser3
1Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Translational Vision Science & Technology
|November 7, 2022
Summary
Pupil contractility varies with iris color and age, as shown by optical coherence tomography (OCT) pupillometry. Darker irises and younger age correlate with greater pupillary response.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Human Physiology
Background:
- Pupillary light reflex is crucial for visual function.
- Variability in pupillary response is influenced by various factors.
- Optical coherence tomography (OCT) offers high-resolution imaging of ocular structures.
Purpose of the Study:
- To analyze natural variability in pupillary contractility using dynamic OCT pupillometry.
- To investigate the influence of iris color, age, and sex on pupillary response in healthy Caucasians.
Main Methods:
- Retrospective analysis of anterior segment swept-source OCT volumes from 71 healthy eyes.
- Measurement of baseline scotopic and photopic intrapupillary spaces (IPSs).
- Assessment of pupillary ejection fraction (PEF), 3D contractility, and relative light response (RLR).
Main Results:
- More pigmented irises exhibited greater contractility.
- Iris color significantly affected scotopic IPSs, PEF, 3D contractility, and RLR (P < 0.05).
- Age correlated with decreased absolute scotopic volume and 3D contractility (P < 0.05); sex showed no correlation.
Conclusions:
- Dynamic OCT pupillometry effectively analyzes natural variability in pupillary contractility.
- Iris color and age are significant factors influencing pupillary response measured by OCT pupillometry.
