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Updated: Aug 22, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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The human batokine EPDR1 regulates β-cell metabolism and function

Luis Rodrigo Cataldo1, Qian Gao2, Lidia Argemi-Muntadas2

  • 1The Novo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200 Denmark; Lund University Diabetes Centre, Clinical Research Center, Sweden; Department of Clinical Sciences in Malmö, Lund University, Sweden.

Molecular Metabolism
|November 7, 2022
PubMed
Summary

Ependymin-Related Protein 1 (EPDR1) upregulation in type 2 diabetes may enhance pancreatic beta-cell function by improving glucose metabolism and insulin secretion. This protein aids in channeling pyruvate to the TCA cycle, crucial for glucose homeostasis.

Keywords:
Beta cellsInsulin secretionLactateMitochondrial metabolismTCA cycleType 2 diabetes

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