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Updated: Aug 22, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Cost drivers in endovascular pulmonary embolism interventions
T E Callese1, J M Moriarty1, C Maehara2
1Division of Interventional Radiology, Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Endovascular pulmonary embolism interventions vary significantly in cost. Mechanical aspiration thrombectomy is the most expensive, while catheter-directed thrombolysis is the least costly.
Area of Science:
- Interventional Cardiology
- Health Economics
- Medical Device Technology
Background:
- Pulmonary embolism (PE) is a life-threatening condition requiring timely intervention.
- Endovascular techniques offer minimally invasive treatment options for PE.
- Understanding the cost implications of different PE interventions is crucial for healthcare resource allocation.
Purpose of the Study:
- To determine and compare the procedural costs of various endovascular pulmonary embolism interventions.
- To identify cost drivers within different intervention methods.
Main Methods:
- Time-driven activity-based costing (TDABC) was utilized to calculate procedural costs.
- Multidisciplinary teams developed process maps detailing personnel, space, equipment, materials, and time for each step.
- Institutional and publicly available financial data were used to determine costs and capacity cost rates.
Main Results:
- Catheter-directed thrombolysis (CDT) was the least expensive ($3,889), while mechanical aspiration thrombectomy (MAT) was the most expensive ($13,748.01).
- Tissue plasminogen activator (tPA) represented a significant portion of material costs for CDT (46.4%), PMT (13.1%), and USAT (10.8%).
- Intensive care unit (ICU) costs were highest for CDT (33.4%) compared to USAT (13.5%) and PMT (13.1%).
Conclusions:
- Endovascular pulmonary embolism intervention costs range significantly, with large-bore mechanical aspiration techniques being the most expensive.
- Catheter-directed thrombolysis is the most cost-effective option among the evaluated interventions.
- Physician-driven device selection significantly impacts procedural costs, necessitating a balance between cost, technical success, and clinical outcomes for optimal healthcare value.
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