Prognostic value of the novel P/FPE index to classify ARDS severity: A cohort study

To evaluate the impact of the novel P/FP_E index to classify ARDS severity on mortality of patients with ARDS.

A retrospective cohort study.

Twelve-bed medical and surgical intensive care unit from January 2018 to December 2020.

A total of 217 ARDS patients managed with invasive mechanical ventilation >48h.

None.

ARDS severity on day 1 and day 3 was measured based on PaO₂/FiO₂ ratio and P/FP_E index [PaO₂/(FiO₂×PEEP)]. Primary outcome was the hospital mortality.

Hospital mortality rate was 59.9%. Relative to PaO₂/FiO₂ ratio, 31.8% of patients on day 1 and 77.0% on day 3 were reclassified into a different category of ARDS severity by P/FP_E index. The level of PEEP was lower by P/FP_E index-based ARDS severity classification than by using PaO₂/FiO₂ ratio. The performance for predicting mortality of P/FP_E index was superior to PaO₂/FiO₂ ratio in term of AROC (day 1: 0.72 vs. 0.62; day 3: 0.87 vs. 0.68) and CORR (day 1: 0.370 vs. 0.213; day 3: 0.634 vs. 0.301). P/FP_E index improved prediction of risk of death compared to PaO₂/FiO₂ ratio as showed by the qNRI (day 1: 72.0%, p<0.0001; day 3: 132.4%, p<0.0001) and IDI (day 1: 0.09, p<0.0001; day 3: 0.31, p<0.0001).

Assessment of ARDS severity based on P/FP_E index seems better than PaO₂/FiO₂ ratio for predicting mortality. The value of P/FP_E index for clinical decision-making requires confirmation by randomized controlled trials.