Related Experiment Video

Updated: Aug 22, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Opioid toxicity: histamine, hypersensitivity, and MRGPRX2

Brian A Baldo1,2, Nghia H Pham3,4

  • 1Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, Sydney, NSW, 2065, Australia. babaldo@iinet.net.au.

Archives of Toxicology
|November 7, 2022
PubMed
Summary

Research reveals the mast cell receptor MRGPRX2 mediates non-immune drug reactions. Opioid drugs activate MRGPRX2, causing histamine release and adverse effects like flushing. Further studies will clarify the link between MRGPRX2 activation and opioid-induced reactions.

Keywords:
MRGPRX2Morphine and MRGPRX2Opioids, MRGPRX2 and adverse reactionsOpioids, MRGPRX2, pseudoallergies, and hypersensitivityOpioids, histamine and MRGPRX2Opioids, histamine, MRGPRX2 and pseudoallergies

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