Related Experiment Video

Updated: Aug 22, 2025

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.3K

Uveitic glaucoma in children: a systematic review on surgical outcomes

Charlotte L L I van Meerwijk1, Nomdo M Jansonius2, Leonoor I Los2

  • 1Department of Ophthalmology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands. c.l.l.i.van.meerwijk@umcg.nl.

Journal of Ophthalmic Inflammation and Infection
|November 7, 2022
PubMed

Insights

Surgical interventions for secondary glaucoma in pediatric uveitis significantly lower intraocular pressure (IOP). However, study quality is low, and complications are frequent, necessitating further research for optimal treatment strategies.

Area of Science:

  • Ophthalmology
  • Pediatric Surgery
  • Glaucoma Research

Background:

  • Pediatric uveitis can lead to secondary glaucoma, a serious condition requiring surgical management.
  • Effective surgical interventions are crucial for preventing vision loss in affected children.

Purpose of the Study:

  • To systematically review and compare surgical interventions for secondary glaucoma in pediatric uveitis.
  • To assess outcomes such as intraocular pressure (IOP) and complications associated with these surgeries.

Main Methods:

  • Systematic review adhering to PRISMA standards.
  • Inclusion of studies with pediatric patients (≤16 years) undergoing glaucoma surgery for uveitis with ≥1 year follow-up.
  • GRADE approach used to assess study quality; primary outcomes included IOP and medication use.

Main Results:

  • Fourteen studies evaluated six different surgical procedures.
  • All interventions significantly reduced IOP and the need for IOP-lowering medications.
  • Cyclophotocoagulation showed the lowest success rates; common complications included ocular hypertension, hypotony, and hyphema, often requiring reoperation.

Conclusions:

  • Surgical interventions play a vital role in preventing blindness by controlling medically uncontrolled IOP in pediatric glaucoma secondary to uveitis.
  • Current evidence is of low to very low quality, precluding definitive preferences for any specific surgical method.
  • Further research with larger sample sizes and direct comparative studies is essential to identify the most effective glaucoma treatments for this population.
Abstract

Keywords:
ChildhoodGlaucomaPediatric uveitisSurgerySurgical outcomes

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.5K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.6K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
695
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
525
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
622