Related Experiment Video
Updated: Aug 22, 2025
Knee Arthrocentesis in Adults
Published on: February 25, 2022
Comparison between peri-articular injection and intra-articular injection of tranexamic acid during total knee
Yue Liu, Yao-Min Li, Peng Tian
1Department of Orthopedics, Tianjin University Tianjin Hospital, 300211 Tianjin, China. fuxinxin.1985@163.com.
Objectives:
In this meta-analysis, we aimed to compare the efficacy and safety of peri-articular injection (PAI) and intraarticular injection (IAI) of tranexamic acid (TXA) in total knee arthroplasty (TKA).
Patients And Methods:
We performed a comprehensive literature search from electronic databases such as Springer, Web of Science, PubMed, Cochrane Library databases, and ScienceDirect up to October 2021. The language of identified articles was not restricted. The keywords used for the search strategy included: "tranexamic acid", "total knee arthroplasty", "peri-articular injection" and "intra-articular injection".
Results:
Two randomized-controlled trials (RCTs) and four non-RCTs with a total of 491 patients met the inclusion criteria. Of the patients, 242 patients were in the PAI group and 249 patients were in the IAI group. No significant difference was observed between the two groups in hemoglobin drop, postoperative drainage volume, total blood loss, blood transfusion requirements, or units of blood transfused. There was no significant difference between the two groups regarding postoperative infection or deep venous thrombosis.
Conclusion:
The PAI of TXA is comparable to IAI of TXA in decreasing postoperative blood loss during TKA.
