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Protein Informatics and Vaccine Development: Cancer Case Study

Saroj Verma1, Neeraj Masand2, Rameshwar S Cheke3

  • 1Department of Pharmacy, Physiopharmacotherapia Centre of Excellence, School of Medical and Allied Sciences, K.R. Mangalam University, Gurugram, 122103, India.

Current Topics in Medicinal Chemistry
|November 8, 2022
PubMed

Clinical translation is a challenging step in the development of cancer vaccines and is found to be related to the complex nature of cancer immunology. Vaccine-based therapeutic strategies for cancer have gained consideration with the advent of vaccine technology as well as an understanding of cancer immunology. Immunotherapy has been widely used in the treatment of cancer. Some promising candidates have been identified to engineer cancer vaccines like Glycoprotein, Mucin 1, MHC protein, etc. It has benefited from the availability of advanced techniques for rapid identification and selection of proteins for precision engineering. Simultaneously, nanovaccines have been focused on target delivery and artificial intelligence-based approaches for personalized vaccine development. The manuscript summarizes the advances in the development of structurebased cancer vaccines along with the status of clinical studies and applications.

Keywords:
Cancer vaccinesClinical trialsImmunotherapyNano vaccines.Oncolytic vaccinesPersonalized cancer vaccinesStructure-based vaccines

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